The research mission of this section is to study basic processes in molecular cell biology to generate novel, fundamental insights related to cellular and organismal fitness. Through high quality research, we aim to identify and, where possible, exploit science-based targets to promote healthy aging or treat human disease.
Molecular Cell biology studies how cells maintain their function and what leads to their dysfunction. Fundamental insight into cell biological processes is key to understand how genetics or environment affect human health or lead to disease.
Within the section Molecular Cell Biology of the Department of Biomedical Science of Cells and Systems, at the UMCG, several aspects of cell biology are studied. These include protein homeostasis, protein complex remodeling, and organelle maintenance and sorting. Model systems include yeast, mammalian cell and (patient-derived) iPS cell models, somatic stem cells, organoids and organotypic slice models, and Drosophila and mouse models. Diseases studied encompass neurodegenerative diseases, (cardio)myopathies, gastroenterological diseases, dermatological diseases, and oncology. Our section (and department) has a formal link with the Department of Radiological Oncology.
The section runs facility centers for Drosophila research, offering a variety of disease and aging models, and for Molecular Imaging (UMIC), providing state-of-the-art systems for confocal light Microscopy and Electron Microscopy.
Research in the section is supported by the UMCG, the University Groningen, and a wide array of scientific (NWO, EU) and charity foundations (including Dutch MS Research Foundation, Dutch Brain foundation, Dutch Heart Foundation, Dutch Cancer Society).