Autophagy is an intracellular catabolic pathway conserved among all eukaryotes. Autophagy is crucial to maintain cellular homeostasis by sequestering and delivering unwanted proteins, complexes and organelles, to lysosomes for their degradation. This process thus participates to the adaptation to starvation, development, degradation of aberrant structures, lifespan extension, immunity and type II programmed cell death. Autophagy also plays a relevant role in the pathophysiology of neurodegenerative, cardiovascular, chronic inflammatory, muscular and autoimmune diseases, and some malignancies. Crucially, it has also been shown that autophagy is an effective therapy to prevent or cure diseases, including specific types of tumors, muscular dystrophies and neurodegenerative disorders. The elucidation of the mechanism of autophagy is therefore vital to understand the regulation and contribution of this pathway in the different physiological and pathological situations, and to modulate it to the benefit of human health.

The functional and physiological roles of autophagy have also attracted the interest of several investigators at the University of Groningen. As a result, the Groningen Autophagy Group was created in 2016 with the goal of promoting the sharing of local expertise, reagents and eventually initiate common research lines.

[[Participating groups

  • Prof. Dr. Harm Kampinga, Department of Cell biology, UMCG (website)
  • Dr. Muriel Mari, Department of Cell Biology, UMCG (website)
  • Prof. Dr. Fulvio Reggiori, Department of Cell Biology, UMCG (website)

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[[Local Events

To be announced

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[[International Events

  • 2017 EMBO conference on Autophagy: From molecular principles to human diseases, September 25-29, Dubrovnik, Croatia (website)
  • 2017 Buenos Aires Research Conference on Autophagy, October 23-25, Buenos Aires, Argentina (website)  
  • 2018 Gordon Research Conferences on Autophagy in Stress, Development & Disease, March 18-23, Il Ciocco, Lucca, Italy (website)
  • 2018 Keystone Symposium of Selective Autophagy, April 22-26, Kyoto, Japan (website

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[[News and Publications

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