Research Groups

Baron group

Our research focuses on myelin biogenesis in health and disease (particularly multiple sclerosis, MS) on topics related to trafficking and signalling in oligodendrocytes.

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  • Wia Baron Visit
    Position

    Principal Investigator

    Research fields

    Myelin biogenesis, multiple sclerosis (MS), trafficking and signalling in oligodendrocytes.

    PhD Students
    Technicians
      • Selected Publications: 
      1. Baron W, Ozgen H, Klunder B, de Jonge JC, Nomden A, Plat A, Trifilieff E, de Vries H, Hoekstra D. (2015), The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide. Mol Cell Biol. 35, 288-302. (pdf)
      2. Stoffels JM, de Jonge JC, Stancic M, Nomden A, van Strien ME, Ma D, Siskova Z, Maier O, ffrench-Constant C, Franklin RJ, Hoekstra D, Zhao C, Baron W. (2013), Fibronectin aggregation in multiple sclerosis lesions impairs remyelination. Brain 136, 116-131. (pdf)
      3. Stancic M, Slijepceviv D, Nomden A, Vos MJ, de Jonge JC, Sikkema AH, Gabius HJ, Hoekstra D, Baron W. (2012), Galectin-4, a novel neuronal regulator of myelination. Glia 60, 919-935. (pdf)
      4. Stancic M, van Horssen J, Thijssen VL, Gabius HJ, van der Valk P, Hoekstra D, Baron W (2011), Increased expression of different galectins in multiple sclerosis lesions. Neuropathol Appl Neurobiol 37, 654-671.  (pdf )
      5. Maier O, Baron W, Hoekstra D. (2007), Reduced raft-association of NF155 in active MS-lesions is accompanied by the disruption of the paranodal junction. Glia 55, 885-895.  (pdf)
      6. Maier O, de Jonge JC, Nomden A, Hoekstra D, Baron W. (2009), Lovastatin induces the formation of abnormal myelin-like membrane sheets in primary oligodendrocytes. Glia 57, 402-413.  (pdf)
      7. Siskova Z, Baron W, de Vries H, Hoekstra D. (2006), Fibronectin impedes ‘myelin’ sheet-directed flow in oligodendrocytes: a role for a beta 1 integrin-mediated PKC signaling pathway in vesicular trafficking. Mol Cell Neurosci, 150-159. (pdf)
      8. Baron W, Decker L, Colognato H, ffrench-Constant C. (2003), Regulation of integrin growth factor interactions in oligodendrocytes by lipid raft microdomains. Curr Biol 13, 151-155. (pdf)
      9. Colognato H, Baron W, Avellan-Adaiod V, Relvas JB, Baron-van Evercooren A, Georges-Labouesse E., ffrench-Consant C. (2002), CNS integrin switch growth factor signaling to promote target-dependent survival. Nat Cell Biol. 4, 833-841. (pdf)
      10. Baron W, Shattil SJ, ffrench-Constant C (2002), The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of αvβ3 integrins. EMBO J 21, 833-841. (pdf)
       
  • PhD students:
    Zuzana Šišková (2006)
    Bert Klunder (2007)
    Mirjana Stancic (2012)
    Josephine Stoffels (2014)
    Hande Ozgen (2014)
    Marjolein Bijlard (2016)
    Jing Qin (expected 2017)

    Post-docs:
    Olaf Maier
    Tiemen van der Heide
    Michel Vos
    Erik Sikkema

    Technicians:
    Anita Nomden
    Bojana Mikus

  • We have identified the polarized nature of oligodendrocytes, in which cognate apical-like and basolateral-like trafficking routes exists for transport of protein and lipids to the cell body plasma membrane and myelin membrane, respectively.

    Another aspect of our work aims at revealing the role of neuronal factors and the relevance of various extracellular matrix constituents present in MS lesions that  modulate oligodendrocyte differentiation and myelination.

    We have identified environmental signalling abnormalities in MS lesions, such as fibronectin aggregates and the persistent presence of neuronal galectin-4, that hamper oligodendrocyte maturation.

    Currently we aim to device strategies that reverse signal malfunctioning of fibronectin aggregates and galectin-4 so as to favor the development of therapeutics to promote endogenous remyelination and/or overcome remyelination failure in MS lesions, thereby halting disease progression.

  • Wia Baron is an Associate Professor at the Department of Cell Biology at University Medical Center Groningen (UMCG). Dr. Baron’s research interests lie in the area of myelin biogenesis and myelin repair with emphasis on the disease multiple sclerosis (MS).

    She graduated cum laude in Biochemistry, with Immunology as an additional subject, at the University of Groningen in 1994. In 1999, she received her PhD degree in Medical Sciences from the University of Groningen under Prof. Dick Hoekstra, and has subsequently worked as a postdoctoral fellow at the Cambridge Centre for Brain Repair in Cambrigde (UK) in the group of Prof. Charles ffrench-Constant. Dr. Baron was awarded an MS fellowship (2004) and is a VIDI-Aspasia recipient (2008).

  • MS Center Noord-Nederland (MSCNN)

    (opmerking, men is bezig de MSCNN website te vernieuwen)

  • Student projects:

    Students (bachelor, masters or technician school) who are interested to perform an internship in our group are welcome to apply. We have ample opportunities, and I would be happy to explain our research goals and possibilities for research projects in more detail. Minimal length is 3 months.

    You can apply via this application form.

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