Our research focuses on myelin biogenesis in health and disease (particularly multiple sclerosis, MS) on topics related to trafficking and signalling in oligodendrocytes.
Myelin biogenesis, multiple sclerosis (MS), trafficking and signalling in oligodendrocytes.
Zuzana Šišková (2006)
Bert Klunder (2007)
Mirjana Stancic (2012)
Josephine Stoffels (2014)
Hande Ozgen (2014)
Marjolein Bijlard (2016)
Peng Wang (2018)
Jing Qin (tba)
Tiemen van der Heide
We have identified the polarized nature of oligodendrocytes, in which cognate apical-like and basolateral-like trafficking routes exists for transport of protein and lipids to the cell body plasma membrane and myelin membrane, respectively.
Another aspect of our work aims at revealing the role of neuronal factors and the relevance of various extracellular matrix constituents present in MS lesions that modulate oligodendrocyte differentiation and myelination.
We have identified environmental signalling abnormalities in MS lesions, such as fibronectin aggregates and the persistent presence of neuronal galectin-4, that hamper oligodendrocyte maturation.
Currently we aim to device strategies that reverse signal malfunctioning of fibronectin aggregates and galectin-4 so as to favor the development of therapeutics to promote endogenous remyelination and/or overcome remyelination failure in MS lesions, thereby halting disease progression.
Wia Baron is an Associate Professor at the Department of Cell Biology at University Medical Center Groningen (UMCG). Dr. Baron’s research interests lie in the area of myelin biogenesis and myelin repair with emphasis on the disease multiple sclerosis (MS).
She graduated cum laude in Biochemistry, with Immunology as an additional subject, at the University of Groningen in 1994. In 1999, she received her PhD degree in Medical Sciences from the University of Groningen under Prof. Dick Hoekstra, and has subsequently worked as a postdoctoral fellow at the Cambridge Centre for Brain Repair in Cambrigde (UK) in the group of Prof. Charles ffrench-Constant. Dr. Baron was awarded an MS fellowship (2004) and is a VIDI-Aspasia recipient (2008).
|On the role of macrophages, microglia and the extra-cellular matrix in remyelination.
|Molecular mechanisms regulating myelin biogenesis.
2016, Bijlard, M. (Marjolein) Thesis
|Myelin biogenesis: Dynamics of MBP, PLP and galactolipids.
2014, Ozgen, H. (Hande) Thesis
|Multiple sclerosis, remyelination and the role of fibronectin.
2014, Stoffels, J.M.J. (Josephine) Thesis
|Galectins, (Re)myelination and multiple sclerosis pathology.
2012, Stancic, M. (Mirjana) Summary
|Sorting and trafficking of proteins in oligodendrocytes during myelin membrane biogenesis.
2007, Klunder, B. (Bert) Thesis
|Extracellular matrix and (re)myelination.
2006, Šišková, Z. (Zuzana) Thesis
(opmerking, men is bezig de MSCNN website te vernieuwen)
Students (bachelor, masters or technician school) who are interested to perform an internship in our group are welcome to apply. We have ample opportunities, and I would be happy to explain our research goals and possibilities for research projects in more detail. Minimal length is 3 months.
You can apply via this application form.