Radiotherapy is involved in 75% of all cancer treatments. The dose that can be delivered to the tumor however is limited to the tolerance of the surrounding normal tissues. Therefore, the Coppes lab focusses on the effects of radiation on normal tissues.
Effects of radiation on normal tissues
Alena Novakova Jiresova
Sonja van der Veen
Next to the physiological mechanism interaction within and between irradiated tissues, the lab is interested in the response of stem cells to radiation and subsequent regeneration of damaged tissues. We developed in vivo and in vitro models on purification and characterization of mice, rat and human neuronal, salivary, thyroid gland and esophagus stem/progenitor cells. Recently we developed a protocol for adult stem cell therapy for radiation-induced hyposalivation and consequential xerostomia, which is now being translated to the clinic. Currently, the lab is investigating the possibly to use patient derived tissue and tumor derived organoids as a model to develop personalized medicine.
Rob Coppes obtained his PhD in Molecular Pharmacology at the University of Groningen in 1993. Attracted by the possibility to use a pharmacological approach to attenuate radiation-induced tissue damage he became a post-doctoral fellowship at Department of Radiobiology at the University of Groningen under the supervision of Profs A.W.T. Konings, A. Vissink and later Prof H.H. Kampinga.
In 2000 he moved to the department of Radiotherapy as a clinical radiation biologist and started his own lab at the department of Cell Biology to focus on the effect of irradiation on normal tissues such as, lung and salivary glands. He became a full professor of Radiotherapy with focus on the Radiation Biology of normal tissues in 2012. His lab developed in vivo and in vitro models on purification and characterization of stem/progenitor cells from mice, rat and human salivary and thyroid gland as well as esophagus. This lead to the development of a protocol for adult stem cell therapy for radiation-induced hyposalivation and consequential xerostomia, which is now being translated to the clinic.
Currently, his group is investigating the possibility of using patient derived tumor organoids to develop personalized medicine. In 2015 he received the Bacq-and-Alexander Award of the European Radiation Research Society to an outstanding European researcher to recognize achievements in the field of radiation research.
|1988||MSc Biology, University of Groningen, major Neuropharmacology and Neurophysiology, minor Behavioural Physiology.|
|1993||PhD in Molecular Pharmacology, Faculty of Mathematics and Natural Sciences, University of Groningen, The Netherlands. Modulation of Noradrenergic Neurotransmission by Prejunctional Receptors|
|1993-2000||Post-doctoral fellow in clinical radiobiology at theDept Radiobiology, University of Groningen, The Netherlands|
|2000-2005||Assistant Professor at the Departments of Radiation Oncology and Cell Biology, section Radiation & Stress Cell Biology, the University Medical Center Groningen.|
|2000-present||Clinical Radiation Biologist at the Department of Radiation Oncology of the University Medical Center Groningen.|
|2003-2006||Co-ordinator of the European Commission 6th Framework, Life Sciences, Genomics and Biotechnology for Health Project “FIRST” (2004, Contract no.: 503436).|
|2004-2009||Board Member of the Dutch Radiation Biology Society (NVRB)|
|2005-present||Associate Professor of the Departments of Radiation Oncology and Cell Biology, section Radiation & Stress Cell Biology, University Medical Center Groningen.|
|2009-present||President of the Dutch Radiation Biology Society (NVRB)|
|2011-present||Councillor Biology of the International Association for Radiation Research (IARR)|
|2016||present||Editorial Board Member Stem Cells|
|2016||present||Member of the Scientific Council of the European Society of Radiotherapy and Oncology (ESTRO)|
|2015||present||Chair of the Radiobiology Committee of ESTRO.|
|2015||present||Editor Biology of Radiotherapy and Oncology, Journal of ESTRO.|
|2015||present||Associate senior editor of the International Journal of Radiation Oncology*Biology*Physics.|
|2015||The Bacq-and-Alexander Award of the European Radiation Research Society to an outstanding European researcher to recognise achievements in the field of radiation research.|
|2013||Programme leader of Cancer Research Center Groningen (CRCG) research programme; Damage and Repair in Cancer Development and Cancer Treatment (DARE)|
|2012||present||Full Professor of Radiotherapy with focus on the Radiation Biology of normal tissues
2011-2019: International Association for Radiation Research (IARR) Council Member representing Biology.
|2009||2016||President of the Dutch Radiation Biology Society (NVRB)|
Nagle, P.W.K. (2018). The use of organoids in the study of radiation response and therapeutic window. Short english summary
Wieringa, H. (2017). Targeting the DNA damage response in cervical cancer[Groningen]: Rijksuniversiteit Groningen
Wang, D. (2017). Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation [Groningen]: University of Groningen
Klunder, L. J. (2016). Effects of lifestyle and environmental factors on intestinal epithelial cell morphogenesis [Groningen]: Rijksuniversiteit Groningen
Maimets, M. (2016). Potential of salivary gland stem cells in regenerative medicine[Groningen]: University of Groningen
van der Veen, S. J. (2016). Radiation-induced cardiopulmonary dysfunction: Pathophysiology & Intervention strategies [Groningen]: Rijksuniversiteit Groningen
Pattje, W. J. (2016). Radiosensitivity and metastasis in squamous cell carcinoma of the head and neck: a molecular approach [Groningen]: Rijksuniversiteit Groningen
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Coppes, M. H. (2000). Discogenic low back pain: lumbar spondylodesis revisitedGroningen: s.n.
Coppes, R. C. (1997). Credit and market risk. An analysis of capital requirements for banking institutions
Coppes, R. P. (1993). Modulation of noradrenergic neurotransmission by prejunctional auto- and heteroreceptors in the freely moving rat Drukkerij FEBO Enschede
Coppes, A. H. J. (1948). Maatregelen en instellingen op het gebied der volksgezondheid in de stad van 100.000 inwoners. Groningen: s.n.
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