Research Groups

Coppes group

Radiotherapy is involved in 75% of all cancer treatments. The dose that can be delivered to the tumor however is limited to the tolerance of the surrounding normal tissues. Therefore, the Coppes lab focusses on the effects of radiation on normal tissues.

  • People
  • Publications
  • Alumni
  • Research
  • Biosketch
  • Dissertations
  • Students
  • Rob Coppes Visit
    Position

    Principal Investigator

    Research fields

    Effects of radiation on normal tissues

    Postdoctoral Fellows
    PhD Students
    Andries Groen
    Technicians
      • Selected Publications:
      1. Nagle PW, Hosper NA, Ploeg EM, van Goethem M-J, Brandenburg S, Langendijk JA, ... Coppes RP. (2016). The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers .Int J Rad Oncol Biol Phys , 95(1), 103-111.  (pdf)
      2. Pringle S, Maimets M, van der Zwaag M, Stokman MA, van Gosliga D, Zwart E, ... Coppes RP. (2016). Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands. Stem cells, 34(3), 640-652. (pdf)
      3. Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BNG, ... Coppes RP. (2016).Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports, 150-162. (pdf)
      4. van der Veen SJ, Faber H, Ghobadi G, Brandenburg S, Langendijk JA, Coppes RP, van Luijk P.  (2016). Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects.  Int J Rad Oncol Biol Phys , 94(1), 163-171.  (pdf)
      5. Ghobadi G, Wiegman EM, Langendijk JA, Widder J, Coppes RP, van Luijk P. (2015). A new CT-based method to quantify radiation-induced lung damage in patients. Radiotherapy and Oncology, 117(1), 4-8. (pdf)
      6. van Luijk P, Pringle S, Deasy JO, Moiseenko VV, Faber H, Hovan A, ... Coppes RP. (2015). Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer. Science Translational Medicine, 7(305), 305-147.  (pdf)
      7. van der Veen SJ, Ghobadi G, de Boer RA, Faber H, Cannon MV, Nagle PW, ... Coppes RP. (2015). ACE inhibition attenuates radiation-induced cardiopulmonary damage. Radiotherapy and Oncology, 114(1), 96-103.  (pdf)
      8. Vissink A, van Luijk P, Langendijk JA, Coppes RP. (2015). Current ideas to reduce or salvage radiation damage to salivary glands. Oral diseases, 21(1), E1-E10. (pdf)
      9. Nanduri LS, Baanstra M, Faber H, Rocchi C, Zwart E, de Haan G, van Os R, Coppes RP. (2014) Purification and ex vivo expansion of fully functional salivary gland stem cells. Stem Cell Reports. 2014 Dec 9;3(6):957-64.   (pdf)
  • Postdocs:
    Maarten Niemantsverdriet
    Sarah Pringle
    Nynke Hosper

    PhD students:
    Ghazaleh Ghodabi
    Isabelle Lombaert
    Martti Maimets
    Lalitha Nanduri
    Alena Novakova Jiresova
    Justin Smit
    Sonja van der Veen
    Erwin Wiegman

     

  • Next to the physiological mechanism interaction within and between irradiated tissues, the lab is interested in the response of stem cells to radiation and subsequent regeneration of damaged tissues. We developed in vivo and in vitro models on purification and characterization of mice, rat and human neuronal, salivary, thyroid gland and esophagus stem/progenitor cells. Recently we developed a protocol for adult stem cell therapy for radiation-induced hyposalivation and consequential xerostomia, which is now being translated to the clinic. Currently, the lab is investigating the possibly to use patient derived tissue and tumor derived organoids as a model to develop personalized medicine.

    Current projects:

    • ZonMW: Development of a 3D matrix for the culturing of adult tissue stem cells for therapeutic purposes
    • Stichting Tekke Huizinga Fonds: Adult stem cells of the murine and human thyroid gland: expansion and functionality
    • ZonMw: Transplantation of Adult Salivary Gland Stem Cells to Restore Salivary Gland Function after Radiotherapy
    • Dutch Cancer Society: Cell therapy to reduce radiation-toxicity to salivary glands
  • Rob Coppes obtained his PhD in Molecular Pharmacology at the University of Groningen in 1993. Attracted by the possibility to use a pharmacological approach to attenuate radiation-induced tissue damage he became a post-doctoral fellowship at Department of Radiobiology at the University of Groningen under the supervision of Profs A.W.T. Konings, A. Vissink and later Prof H.H. Kampinga.

    In 2000 he moved to the department of Radiotherapy as a clinical radiation biologist and started his own lab at the department of Cell Biology to focus on the effect of irradiation on normal tissues such as, lung and salivary glands. He became a full professor of Radiotherapy with focus on the Radiation Biology of normal tissues in 2012. His lab developed in vivo and in vitro models on purification and characterization of stem/progenitor cells from mice, rat and human salivary and thyroid gland as well as esophagus. This lead to the development of a protocol for adult stem cell therapy for radiation-induced hyposalivation and consequential xerostomia, which is now being translated to the clinic.

    Currently, his group is investigating the possibility of using patient derived tumor organoids to develop personalized medicine. In 2015 he received the Bacq-and-Alexander Award of the European Radiation Research Society to an outstanding European researcher to recognize achievements in the field of radiation research.


    1988 MSc Biology, University of Groningen, major Neuropharmacology and Neurophysiology, minor Behavioural Physiology.
    1993 PhD in Molecular Pharmacology, Faculty of Mathematics and Natural Sciences, University of Groningen, The Netherlands. Modulation of Noradrenergic Neurotransmission by Prejunctional Receptors
    1993-2000 Post-doctoral fellow in clinical radiobiology at theDept Radiobiology, University of Groningen, The Netherlands
    2000-2005 Assistant Professor at the Departments of Radiation Oncology and Cell Biology, section Radiation & Stress Cell Biology, the University Medical Center Groningen.
    2000-present Clinical Radiation Biologist at the Department of Radiation Oncology of the University Medical Center Groningen.
    2003-2006 Co-ordinator of the European Commission 6th Framework, Life Sciences, Genomics and Biotechnology for Health Project “FIRST” (2004, Contract no.: 503436).
    2004-2009 Board Member of the Dutch Radiation Biology Society (NVRB)
    2005-present Associate Professor of the Departments of Radiation Oncology and Cell Biology, section Radiation & Stress Cell Biology, University Medical Center Groningen.
    2009-present President of the Dutch Radiation Biology Society (NVRB)
    2011-present Councillor Biology of the International Association for Radiation Research (IARR)

     

    Professional Experience/Appointments:

    2016 present Editorial Board Member Stem Cells
    2016 present Member of the Scientific Council of the European Society of Radiotherapy and Oncology (ESTRO)
    2015 present Chair of the Radiobiology Committee of ESTRO.
    2015 present Editor Biology of Radiotherapy and Oncology, Journal of ESTRO.
    2015 present Associate senior editor of the International Journal of Radiation Oncology*Biology*Physics.
    2015 The Bacq-and-Alexander Award of the European Radiation Research Society to an outstanding European researcher to recognise achievements in the field of radiation research.
    2013 Programme leader of Cancer Research Center Groningen (CRCG) research programme; Damage and Repair in Cancer Development and Cancer Treatment (DARE)
    2012 present Full Professor of Radiotherapy with focus on the Radiation Biology of normal tissues
    2011-2019: International Association for Radiation Research (IARR) Council Member representing Biology.
    2009 2016 President of the Dutch Radiation Biology Society (NVRB)

     

  • All dissertations supervised by Rob Coppes (promotor or advisor)

    Prediction and prevention of radiation induced lung toxicity
    2014, Wiegman,E.M. (Erwin)
    CRCG / DARE: Damage and Repair in Cancer Development and Cancer Treatment

    Concurrent chemoradiotherapy is considered treatment of choice for locally advanced non–small-cell lung cancer. However, the dose that can be safely applied to the tumour is limited by the risk of Radiation Induced Lung Toxicity (RILT). Up to 20% of patients treated with a curative dose may have symptoms and signs of RILT. RILT may present in two phases: acute inflamma¬t…

    » read more

    Salivary gland stem cells
    2014, Nanduri,L.S.Y. (Lalitha)
    CRCG / DARE: Damage and Repair in Cancer Development and Cancer Treatment

    Salivary glands of head and neck cancer patients undergoing radiotherapy are often unavoidably exposed to radiation. The resulting damage impairs the function of salivary gland leading to irreversible dry mouth syndrome (xerostomia), which induces a severe life-long loss of quality of life of the patient. Currently no adequate treatments are available. Salivary gland stem ce…

    » read more

    Pathophysiology of thoracic irradiation
    2013, Ghobadi,G. (Ghazaleh)
    GUIDE / NNOC: Northern Netherlands Oncology Centre

    Radiation treatment plays an important role in the treatment of thoracic tumors 1,2. The efficacy of the treatment however, is limited by the sensitivity of unavoidably co-irradiated healthy tissues 3-9. In thoracic radiotherapy depending on the type, size and location of the tumor, parts of the healthy lung and/or heart are co-irradiated with the tumor causing toxicitie…

    » read more

  • Student projects:

    • Radiation response of normal tissue and tumor stem cells
    • Involvement of YAP/TAS pathway in salivary gland stem cells maintenance.
    • Notch signalling in salivary gland stem cells
    • Role of GDNF in salivary gland stem cell expansion
    • Thyroid gland stem cells expansion

    You can apply via this application form.

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