Autophagy is a catabolic transport route conserved among all eukaryotes that allows the degradation of large portions of the cytoplasm, protein aggregates, excess or damaged organelles and invading pathogens.
Head of the section Molecular Cell Biology, Professor, Principal Investigator
1) The regulation and mechanism of autophagy (in yeast Saccharomyces cerevisiae) 2) Autophagy-pathogen interactions
Jana Sanchez-Wandelmer (2012 – 2016)
Henning Arlt (2014-2016)
Muriel Mari (2006 – 2015)
Eduardo Cebollero (2008-2012)
Kristy Horan (2012)
Iryna Monastyrska (2007–2010)
Adabella van der Zand (2009-2010, visiting postodoctoral fellow)
Rodrigo Guimaraes (2013-2017)
Xingdong Zhou (2016-2017)
Andri Fraenkl (2013-2016)
Susana Abreu (2012-2016)
Leticia Lemus (2015, visiting PhD student)
Joanna Liiv (2014, visiting PhD student)
Ester Rieter (2008-2012)
Shan Shan Wang (2012, visiting PhD student)
Mustafa Ulasli (2007-2011)
Aniek van der Vaart (2006-2010)
Nian Liu (2008, visiting PhD student)
Daria Romanyuk (2008, visiting PhD student)
Despina Xanthakis (2012–2015)
Janice Griffith (2005–2012)
Fleur Broek (2016)
Wouter Huiting (2015)
Alex Jones (2014)
Philip Vkovski (2013)
Mareike Nolte (2012)
Stephanie Keppes (2010–2011)
Ana Maria Guzman-Prieto (2010)
Dorothee van Breevoort (2008-2009)
Fabian Finke (2007-2008)
Ester Rieter (2007-2008)
Jiang Jieqing (2007-2008)
Lakshmi Krishnappa (2007-2008)
Rianne Grond (2016)
Kerst-Jan Hijlkema (2015-2016)
Elena Iskandarani (2012)
Remko Goossens (2010)
Marinke van Oorschot (2009-2010)
Nina Bakker (2009-2010)
Wresti Listu Anggayasti (2009)
Tineke Hoefnagel (2008)
Tessa Hoogenhuijzen (2007)
Jan Hazeleger (2006)
Autophagy is a catabolic process highly conserved among eukaryotes, which is involved in the degradation of long-lived proteins, aberrant complexes and aggregates, dysfunctional and superfluous organelles, and intracellular pathogens. Structures targeted to destruction are sequestered by double-membrane vesicles called autophagosomes and delivered to lysosomes for turnover. The resulting metabolites are reused by the cell as either an energy source or building blocks for the synthesis of new macromolecules.
Autophagy is essential to maintain cellular and organismal homeostasis because involved in the adaptation to stresses, quality control, metabolism regulation, cell development and differentiation, stemness maintenance, type II program cell death, tumor suppression and immunity. As a result, the impairment or defect in autophagy leads to severe pathologies such as neurodegeneration, myopathies, chronic inflammations and some malignancies. Crucially, it has also been shown that autophagy is an effective therapy to prevent or cure diseases, including specific types of tumors, muscular dystrophies and neurodegenerative disorders. The 2016 Nobel Prize in Medicine or Physiology to Prof. Ohsumi, a leading scientist in the field, underlines the recognized importance of autophagy in medical and life sciences.
The elucidation of the mechanisms involved in activation and regulation of autophagy, but also the identification of the proteins required for recognition and elimination of the various autophagic cargoes, is therefore of primary relevance. Understanding the exact role of autophagy in the various physiological situations and pathological conditions is also crucial. All this knowledge combined is essential to be able to modulate autophagy to the benefit of human health, but also for biotechnological and agricultural applications.
The laboratory has two major research lines. In the first, we aim in unveiling the regulation and molecular mechanism of autophagy, and for these studies we use yeast Saccharomyces cerevisiae as a model system. As the long-term objective is to understand the exact contribution of autophagy in specific physiological and pathological contexts, the goal of the second research line has been to understand the interaction between autophagy and pathogens, in particular viruses. In doing this, our interests have also moved to the characterization of unconventional, not autophagy-linked, function of the autophagy proteins.
Fulvio Reggiori (1970) studied Biochemistry at University of Fribourg, Switzerland, and in 1997, he obtained his PhD in Biochemistry from the same Institution. Here, in the laboratory of Prof. Andreas Conzelmann, he has worked on the remodelling of the lipid moiety of GPI-anchored proteins and on sphingolipid biosynthesis in yeast Saccharomyces cerevisiae.
After staying one additional year in the same laboratory as a postodoctoral fellow, he moved to the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, in 1998. There, in the laboratory of Dr. Hugh Pelham, he has investigated the signals targeting integral membrane proteins into the internal vesicles of multivesicular bodies.
In 2001, he joined the laboratory of Prof. Daniel Klionsky at the Life Sciences Institute of the University of Michigan in Ann Arbor (USA). There, he started working on different aspects of the molecular mechanism of autophagy in yeast.
In 2005, Fulvio Reggiori was appointed as a tenured Assistant Professor at the Department of Cell Biology of the University Medical Center Utrecht, where he started is independent research career working on the molecular mechanism of autophagy. The laboratory interests also extended to pathogens that subvert autophagy to invade host cells. In 2011, he became an Associate professor at the same Institution.
In 2015, Fulvio Reggiori became Professor at the Department of Cell Biology of the University Medical Center Groningen, where he is contuining his investigation on the molecular mechanism of autophagy in yeast and on the interaction between pathogens and the ATG proteins.
1994 – 1997 PhD study at the Department of Biochemistry of the University of Fribourg, Switzerland (Supervisor: Prof. A. Conzelmann).
1997 – 1998 Postdoctoral fellow at the Department of Biochemistry of the University of Fribourg, Switzerland, with Prof. Andreas Conzelmann.
1998 – 2001 Postdoctoral fellow in the MRC Laboratory of Molecular Biology Cambridge, United Kingdom, with Dr. Hugh R.B. Pelham.
2001 – 2005 Postdoctoral fellow at the Life Sciences Institute and the Department of Molecular, Cellular, and Developmental Biology of the University of Michigan, Ann Arbor, United States of America, with Prof. Daniel Klionsky.
2005 – 2011 Tenured assistant professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.
2011 – 2014 Associate professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.
2014 – current Professor at the Department of Cell Biology of the University Medical Center Groningen, The Netherlands.
2016 – 2020 Dutch representative in the managing committee of the European Cooperation in Science and technology (COST) Transautophagy
Awards and honors
1993 – 1994 CIBA-GEIGY prize for the best 1993/1994 graduation curriculum in chemistry and biochemistry at the University of Fribourg
1998 – 1999 Swiss National Science Foundation fellowship
1999 – 2001 EMBO long-term fellowship
2001 – 2002 EMBO long-term fellowship
2002 – 2004 Swiss National Science Foundation fellowship for advanced researchers
2006 VIDI award
2007 VICI award
2006 – Utrecht University High Potential grant (with Dr. Xander de Haan)
2006 – ZonMW VIDI grant
2007 – ZonMW Medium Investment grant
2007 – ALW Open Program grant
2010 – CW ECHO grant (with Prof. Bernd Helms)
2010 – NWO-DFG bilateral programme grant (with Prof. Christian Ungermann)
2011 – ALW Open Program grant
2012 – ALW Open Program grant
2013 – ZonMW VICI grant
2014 – Sinergia grant from SNSF (with prof. Matthias Peter and Maurizio Molinari)-
2015 – European Cooperation in Science and technology (COST) cooperation grant
2016 – Marie Skłodowska-Curie Cofund grant
2016 – ZonMW Medium Investment grant
2017 – Marie Skłodowska-Curie Innovative Training Networks (ITN) grant
2017 – ALW Open Program grant
2018 – ZonMW TOP grant (with Prof. Haim Kampinga and Dr. Lukas Kapitein)
Member of the Editorial Board of Autophagy since 2008.
Member of the Editorial Board of Microbial Cell since 2013.
Member of the Editorial Board of Oncotarget since 2015.
Member of the Editorial Board of the Journal of Biological Chemistry since 2016.
Member of the Editorial Board of the BBA Molecular Cell research since 2016.
Member of the Editorial Board of the Journal of International Biochemistry and Cell Biology since 2018.
Aksit, A. (2018). Peroxisomal membrane contact sites in the yeast Hansenula polymorpha [Groningen]: University of Groningen
Rodrigues Abreu, S. (2018). New insights into autophagy regulation using yeast Saccharomyces cerevisiae. [Groningen]: University of Groningen.
Rios Ocampo, W. (2018). Cellular stress response during hepatitis C virus infection: a balancing act between viral persistence and host cell survival. [Groningen]: Rijksuniversiteit Groningen. (Assessment cee,)
van Duijl-Richter, M. (2016). Dengue and Chikungunya virus: Cell entry mechanisms and the impact of antibodies on infectivity [Groningen]: University of Groningen
Yuan, W. (2016). Origin and growth of peroxisomes in yeast: The molecular mechanism of peroxisome formation in yeast [Groningen]: University of Groningen
Although there is currently not a defined research project, the group often hosts students from the different Master Programmes at the University of Groningen. In addition, there are internship possibilities for technician trainees from the different Hogeschools in the Netherlands.
You can apply via this application form.