Research Groups

Reggiori group

Autophagy is a catabolic transport route conserved among all eukaryotes that allows the degradation of large portions of the cytoplasm, protein aggregates, excess or damaged organelles and invading pathogens.

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  • Biosketch
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  • Fulvio Reggiori Visit
    Position

    Professor, Principal Investigator

    Research fields

    1) The regulation and mechanism of autophagy (in yeast Saccharomyces cerevisiae) 2) Autophagy-pathogen interactions

    Postdoctoral Fellows
    PhD Students
    Qianliang Yuan
    Technicians
      • All Publications: mepa page or pdf
      • Selected Publications:
      1. Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F (2016), An siRNA screen for ATG depletion reveals the extent of unconventional functions of the autophagy proteome in virus replication, J Cell Biol, 214, 619-635. (pdf)
      2. Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katon I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I (2015), Regulation of endoplasmic reticulum homeostasis by FAM134B-mediated selective autophagy, Nature, 522, 354-358. (pdf)
      3. Mari M, Geerts WJ, Reggiori F (2014), Immuno- and correlative light microscopy-electron tomography methods for 3D protein localization in yeast, Traffic, 15, 1164-78. (pdf)
      4. Hönscher C, Mari M, Auffarth K, Bohnert M, Griffith J, Geerts W, van der Laan M, Cabrera M, Reggiori F, Ungermann C (2014), Cellular metabolism regulates contact sites of vacuoles with mitochondria, Dev Cell, 30, 86-94. (pdf)
      5. Rieter E, Vinke F, Bakula D, Cebollero E, Ungermann C, Proikas-Cezanne T, Reggiori F (2013), Atg18 function in autophagy is regulated by specific sites within its β-propeller, J Cell Sci, 126, 593-604.  (pdf)
      6. Cebollero E, van der Vaart A, Zhao M, Rieter E, Klionsky DJ, J. Helms B, Reggiori F (2012), Phosphatidylinositol-3-phosphate clearance plays a key role in autophagosome completion, Curr Biol, 22, 1545-1553. (pdf)
      7. Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen W-L, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F*, Melia TJ, Klionsky DJ (2011), SNARE proteins are required for macroautophagy, Cell, 146, 290-302. *co-corresponding author (pdf)
      8. Mari M, Griffith J, Rieter E, Krishnappa L, Klionsky DJ, Reggiori F (2010), An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis, J Cell Biol, 190, 1005-1022.  (pdf)
      9. van der Vaart A, Griffith J, Reggiori F (2010), Exit from the Golgi is required for the expansion of the autophagosomal phagophore in the yeast Saccharomyces cerevisiae, Mol Biol Cell, 21, 2270–2284.  (pdf)
      10. Reggiori F, Monastyrska I, Verheije MH, Calì’ T, Ulasli M, Bianchi S, Bernasconi R, de Haan CAM, Molinari M (2010), Coronaviruses hijack LC3-I-positive EDEMosome membranes for replication, Cell Host Microbe, 7, 500-508. *co-corresponding author  (pdf)
  • (Visiting) postdoctoral fellows:
    Jana Sanchez-Wandelmer (2012 – 2016)
    Henning Arlt (2014-2016)
    Muriel Mari (2006 – 2015)
    Eduardo Cebollero (2008-2012)
    Kristy Horan (2012)
    Iryna Monastyrska (2007–2010)
    Adabella van der Zand (2009-2010, visiting postodoctoral fellow)

    PhD students:

    Andri Fraenkl (2013-2016)

    Susana Abreu (2012-2016)
    Leticia Lemus (2015, visiting PhD student)
    Joanna Liiv (2014, visiting PhD student)
    Ester Rieter (2008-2012)
    Shan Shan Wang (2012, visiting PhD student)
    Mustafa Ulasli (2007-2011)
    Aniek van der Vaart (2006-2010)
    Nian Liu (2008, visiting PhD student)
    Daria Romanyuk (2008, visiting PhD student) 

    Technicians:
    Despina Xanthakis (2012–2015)
    Janice Griffith (2005–2012)

    Master students:

    Fleur Broek (2016)

    Wouter Huiting (2015)
    Alex Jones (2014)
    Philip Vkovski (2013)
    Mareike Nolte (2012)
    Stephanie Keppes (2010–2011)
    Ana Maria Guzman-Prieto (2010)
    Dorothee van Breevoort (2008-2009)
    Fabian Finke (2007-2008)
    Ester Rieter (2007-2008)
    Jiang Jieqing (2007-2008)
    Lakshmi Krishnappa (2007-2008)

    Technician trainees:

    Rianne Grond (2016)
    Kerst-Jan Hijlkema (2015-2016)
    Elena Iskandarani (2012)
    Remko Goossens (2010)
    Marinke van Oooschot (2009-2010)
    Nina Bakker (2009-2010)
    Wresti Listu Anggayasti (2009)
    Tineke Hoefnagel (2008)
    Tessa Hoogenhuijzen (2007)
    Jan Hazeleger (2006)

  • Autophagy participates in a multitude of cellular processes including adaptation to stress conditions such as nutrient deprivation, cell differentiation and development, degradation of aberrant structures, lifespan extension, type II programmed cell death, innate and adaptive immunity. As a result, this pathway plays a relevant role in the pathophysiology of numerous diseases including neurodegenerative, cardiovascular, chronic inflammatory, muscular and autoimmune diseases, and some malignancies.

    Conversely, a deficiency in this protective transport route leads to diseases such as cancers, chronic infections, cardiomyopathies and neurodegeneration. The elucidation of the molecular mechanism of autophagy is therefore vital to understand the regulation and contribution of this pathway in all these physiological and pathological situations, and it is the main objective of the research performed in the Reggiori laboratory.

    The elucidation of the molecular mechanism of autophagy is therefore vital to understand the regulation and contribution of this pathway in all these physiological and pathological situations, and it is the main objective of the research performed in the Reggiori laboratory.
    Figure Autophagy

  • Fulvio Reggiori (1970) studied Biochemistry at University of Fribourg, Switzerland, and in 1997, he obtained his PhD in Biochemistry from the same Institution. Here, in the laboratory of Prof. Andreas Conzelmann, he has worked on the remodelling of the lipid moiety of GPI-anchored proteins and on sphingolipid biosynthesis in yeast Saccharomyces cerevisiae.

    After staying one additional year in the same laboratory as a postodoctoral fellow, he moved to the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, in 1998. There, in the laboratory of Dr. Hugh Pelham, he has investigated the signals targeting integral membrane proteins into the internal vesicles of multivesicular bodies.

    In 2001, he joined the laboratory of Prof. Daniel Klionsky at the Life Sciences Institute of the University of Michigan in Ann Arbor (USA). There, he started working on different aspects of the molecular mechanism of autophagy in yeast.

    In 2005, Fulvio Reggiori was appointed as a tenured Assistant Professor at the Department of Cell Biology of the University Medical Center Utrecht, where he started is independent research career working on the molecular mechanism of autophagy. The laboratory interests also extended to pathogens that subvert autophagy to invade host cells. In 2011, he became an Associate professor at the same Institution.

    In 2015, Fulvio Reggiori became Professor at the Department of Cell Biology of the University Medical Center Groningen, where he is contuining his investigation on the molecular mechanism of autophagy in yeast and on the interaction between pathogens and the ATG proteins.

    Professional career

    1994-1997. PhD study at the Department of Biochemistry of the University of Fribourg, Switzerland (Supervisor: Prof. A. Conzelmann).

    1997-1998. Postdoctoral fellow at the Department of Biochemistry of the University of Fribourg, Switzerland, with Prof. Andreas Conzelmann.

    1998 – 2001. Postdoctoral fellow in the MRC Laboratory of Molecular Biology Cambridge, United Kingdom, with Dr. Hugh R.B. Pelham.

    2001 – 2005. Postdoctoral fellow at the Life Sciences Institute and the Department of Molecular, Cellular, and Developmental Biology of the University of Michigan, Ann Arbor, United States of America, with Prof. Daniel Klionsky.

    2005 – 2011. Tenured assistant professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

    2011 – 2014. Associate professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

    2014 – current. Professor at the Department of Cell Biology of the University Medical Center Groningen, The Netherlands.

    2016 – 2020. Dutch representative in the managing committee of the European Cooperation in Science and technology (COST) Transautophagy

     

    Awards and honors

    1993-1994. CIBA-GEIGY prize for the best 1993/1994 graduation curriculum in chemistry and biochemistry at the University of Fribourg

    1998-1999. Swiss National Science Foundation fellowship

    1999-2001. EMBO long-term fellowship

    2001-2002. EMBO long-term fellowship

    2002-2004. Swiss National Science Foundation fellowship for advanced researchers

     

    Financial support

    2006 – Utrecht University High Potential grant (with Dr. Xander de Haan)

    2006 – ZonMW VIDI grant

    2007 – ZonMW Medium Investment grant

    2007 – ALW Open Program grant

    2010 – CW ECHO grant (with Prof. Bernd Helms)

    2010 – NWO-DFG bilateral programme grant (with Prof. Christian Ungermann)

    2011 – ALW Open Program grant

    2012 – ALW Open Program grant 2013 – ZonMW VICI grant 2014 – Sinergia grant from SNSF (with prof. Matthias Peter and Maurizio Molinari)

    2015 – European Cooperation in Science and technology (COST) cooperation grant

    2016 – Marie Curie CO-FOUND grant

    2016 – ZonMW Medium Investment grant

     

    Editorial boards

    Member of the Editorial Board of Autophagy since 2008.

    Member of the Editorial Board of Microbial Cell since 2013.

    Member of the Editorial Board of Oncotarget since 2015.

    Member of the Editorial Board of the Journal of Biological Chemistry since 2016.

    Member of the Editorial Board of the BBA Molecular Cell research since 2016.

  • Student projects:

    Although there is currently not a defined research project, the group often hosts students from the different Master Programmes at the University of Groningen. In addition, there are internship possibilities for technician trainees from the different Hogeschools in the Netherlands.

    You can apply via this application form.

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