Research Groups

Reggiori group

Autophagy is a catabolic transport route conserved among all eukaryotes that allows the degradation of large portions of the cytoplasm, protein aggregates, excess or damaged organelles and invading pathogens.

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  • Biosketch
  • Dissertations
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  • Fulvio Reggiori Visit

    Head of the section Molecular Cell Biology, Professor, Principal Investigator

    Research fields

    1) The regulation and mechanism of autophagy (in yeast Saccharomyces cerevisiae) 2) Autophagy-pathogen interactions

    Postdoctoral Fellows
    PhD Students
      • All Publications: mepa page or pdf
      • Selected Publications:
      1. Sánchez-Wandelmer J, Kriegenburg F, Rohringer S, Schuschnig M, Gómez-Sánchez R, Zens B, Abreu S, Hardenberg R, Hollenstein D, Gao J, Ungermann C, Martens S, Kraft C, Reggiori F (2017), Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation, Nat Comm, 6, 295. (pdf)
      2. Abreu S, Kriegenburg F, Gómez-Sánchez R, Mari M, Sánchez-Wandelmer J, Rasmussen MS, Soares Guimarães R, Zens B, Schuschnig M, Hardenberg R, Peter M, Johansen T, Kraft C, Martens S, Reggiori F (2017), Conserved Atg8-recognition sites mediate Atg4 association to autophagosomal membranes and Atg8 deconjugation, EMBO Rep, 18, 765-780. (pdf)
      3. Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F (2016), An siRNA screen for ATG depletion reveals the extent of unconventional functions of the autophagy proteome in virus replication, J Cell Biol, 214, 619-635. (pdf)
      4. Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katon I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I (2015), Regulation of endoplasmic reticulum homeostasis by FAM134B-mediated selective autophagy, Nature, 522, 354-358. (pdf)
      5. Mari M, Geerts WJ, Reggiori F (2014), Immuno- and correlative light microscopy-electron tomography methods for 3D protein localization in yeast, Traffic, 15, 1164-78. (pdf)
      6. Hönscher C, Mari M, Auffarth K, Bohnert M, Griffith J, Geerts W, van der Laan M, Cabrera M, Reggiori F, Ungermann C (2014), Cellular metabolism regulates contact sites of vacuoles with mitochondria, Dev Cell, 30, 86-94. (pdf)
      7. Rieter E, Vinke F, Bakula D, Cebollero E, Ungermann C, Proikas-Cezanne T, Reggiori F (2013), Atg18 function in autophagy is regulated by specific sites within its β-propeller, J Cell Sci, 126, 593-604.  (pdf)
      8. Cebollero E, van der Vaart A, Zhao M, Rieter E, Klionsky DJ, J. Helms B, Reggiori F (2012), Phosphatidylinositol-3-phosphate clearance plays a key role in autophagosome completion, Curr Biol, 22, 1545-1553. (pdf)
      9. Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen W-L, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F*, Melia TJ, Klionsky DJ (2011), SNARE proteins are required for macroautophagy, Cell, 146, 290-302. *co-corresponding author (pdf)
      10. Mari M, Griffith J, Rieter E, Krishnappa L, Klionsky DJ, Reggiori F (2010), An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis, J Cell Biol, 190, 1005-1022.  (pdf)
  • Postdoctoral fellows:

    Jana Sanchez-Wandelmer (2012 – 2016)
    Henning Arlt (2014-2016)
    Muriel Mari (2006 – 2015)
    Eduardo Cebollero (2008-2012)
    Kristy Horan (2012)
    Iryna Monastyrska (2007–2010)
    Adabella van der Zand (2009-2010, visiting postodoctoral fellow)


    PhD students:

    Rodrigo Guimaraes (2013-2017)
    Xingdong Zhou (2016-2017)
    Andri Fraenkl (2013-2016)
    Susana Abreu (2012-2016)
    Leticia Lemus (2015, visiting PhD student)
    Joanna Liiv (2014, visiting PhD student)
    Ester Rieter (2008-2012)
    Shan Shan Wang (2012, visiting PhD student)
    Mustafa Ulasli (2007-2011)
    Aniek van der Vaart (2006-2010)
    Nian Liu (2008, visiting PhD student)
    Daria Romanyuk (2008, visiting PhD student) 



    Despina Xanthakis (2012–2015)
    Janice Griffith (2005–2012)


    Master students:

    Fleur Broek (2016)
    Wouter Huiting (2015)
    Alex Jones (2014)
    Philip Vkovski (2013)
    Mareike Nolte (2012)
    Stephanie Keppes (2010–2011)
    Ana Maria Guzman-Prieto (2010)
    Dorothee van Breevoort (2008-2009)
    Fabian Finke (2007-2008)
    Ester Rieter (2007-2008)
    Jiang Jieqing (2007-2008)
    Lakshmi Krishnappa (2007-2008)


    Technician trainees:

    Rianne Grond (2016)
    Kerst-Jan Hijlkema (2015-2016)
    Elena Iskandarani (2012)
    Remko Goossens (2010)
    Marinke van Oorschot (2009-2010)
    Nina Bakker (2009-2010)
    Wresti Listu Anggayasti (2009)
    Tineke Hoefnagel (2008)
    Tessa Hoogenhuijzen (2007)
    Jan Hazeleger (2006)

  • Autophagy is a catabolic process highly conserved among eukaryotes, which is involved in the degradation of long-lived proteins, aberrant complexes and aggregates, dysfunctional and superfluous organelles, and intracellular pathogens. Structures targeted to destruction are sequestered by double-membrane vesicles called autophagosomes and delivered to lysosomes for turnover. The resulting metabolites are reused by the cell as either an energy source or building blocks for the synthesis of new macromolecules.

    Autophagy is essential to maintain cellular and organismal homeostasis because involved in the adaptation to stresses, quality control, metabolism regulation, cell development and differentiation, stemness maintenance, type II program cell death, tumor suppression and immunity. As a result, the impairment or defect in autophagy leads to severe pathologies such as neurodegeneration, myopathies, chronic inflammations and some malignancies. Crucially, it has also been shown that autophagy is an effective therapy to prevent or cure diseases, including specific types of tumors, muscular dystrophies and neurodegenerative disorders. The 2016 Nobel Prize in Medicine or Physiology to Prof. Ohsumi, a leading scientist in the field, underlines the recognized importance of autophagy in medical and life sciences.

    The elucidation of the mechanisms involved in activation and regulation of autophagy, but also the identification of the proteins required for recognition and elimination of the various autophagic cargoes, is therefore of primary relevance. Understanding the exact role of autophagy in the various physiological situations and pathological conditions is also crucial. All this knowledge combined is essential to be able to modulate autophagy to the benefit of human health, but also for biotechnological and agricultural applications.

    The laboratory has two major research lines. In the first, we aim in unveiling the regulation and molecular mechanism of autophagy, and for these studies we use yeast Saccharomyces cerevisiae as a model system. As the long-term objective is to understand the exact contribution of autophagy in specific physiological and pathological contexts, the goal of the second research line has been to understand the interaction between autophagy and pathogens, in particular viruses. In doing this, our interests have also moved to the characterization of unconventional, not autophagy-linked, function of the autophagy proteins.

    Figure Autophagy

  • Fulvio Reggiori (1970) studied Biochemistry at University of Fribourg, Switzerland, and in 1997, he obtained his PhD in Biochemistry from the same Institution. Here, in the laboratory of Prof. Andreas Conzelmann, he has worked on the remodelling of the lipid moiety of GPI-anchored proteins and on sphingolipid biosynthesis in yeast Saccharomyces cerevisiae.

    After staying one additional year in the same laboratory as a postodoctoral fellow, he moved to the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, in 1998. There, in the laboratory of Dr. Hugh Pelham, he has investigated the signals targeting integral membrane proteins into the internal vesicles of multivesicular bodies.

    In 2001, he joined the laboratory of Prof. Daniel Klionsky at the Life Sciences Institute of the University of Michigan in Ann Arbor (USA). There, he started working on different aspects of the molecular mechanism of autophagy in yeast.

    In 2005, Fulvio Reggiori was appointed as a tenured Assistant Professor at the Department of Cell Biology of the University Medical Center Utrecht, where he started is independent research career working on the molecular mechanism of autophagy. The laboratory interests also extended to pathogens that subvert autophagy to invade host cells. In 2011, he became an Associate professor at the same Institution.

    In 2015, Fulvio Reggiori became Professor at the Department of Cell Biology of the University Medical Center Groningen, where he is contuining his investigation on the molecular mechanism of autophagy in yeast and on the interaction between pathogens and the ATG proteins.

    Professional career

    1994 – 1997 PhD study at the Department of Biochemistry of the University of Fribourg, Switzerland (Supervisor: Prof. A. Conzelmann).

    1997 – 1998 Postdoctoral fellow at the Department of Biochemistry of the University of Fribourg, Switzerland, with Prof. Andreas Conzelmann.

    1998 – 2001 Postdoctoral fellow in the MRC Laboratory of Molecular Biology Cambridge, United Kingdom, with Dr. Hugh R.B. Pelham.

    2001 – 2005 Postdoctoral fellow at the Life Sciences Institute and the Department of Molecular, Cellular, and Developmental Biology of the University of Michigan, Ann Arbor, United States of America, with Prof. Daniel Klionsky.

    2005 – 2011 Tenured assistant professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

    2011 – 2014 Associate professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

    2014 – current Professor at the Department of Cell Biology of the University Medical Center Groningen, The Netherlands.

    2016 – 2020 Dutch representative in the managing committee of the European Cooperation in Science and technology (COST) Transautophagy


    Awards and honors

    1993 – 1994 CIBA-GEIGY prize for the best 1993/1994 graduation curriculum in chemistry and biochemistry at the University of Fribourg

    1998 – 1999 Swiss National Science Foundation fellowship

    1999 – 2001 EMBO long-term fellowship

    2001 – 2002 EMBO long-term fellowship

    2002 – 2004 Swiss National Science Foundation fellowship for advanced researchers

    2006              VIDI award

    2007              VICI award


    Financial support

    2006 – Utrecht University High Potential grant (with Dr. Xander de Haan)

    2006 – ZonMW VIDI grant

    2007 – ZonMW Medium Investment grant

    2007 – ALW Open Program grant

    2010 – CW ECHO grant (with Prof. Bernd Helms)

    2010 – NWO-DFG bilateral programme grant (with Prof. Christian Ungermann)

    2011 – ALW Open Program grant

    2012 – ALW Open Program grant

    2013 – ZonMW VICI grant

    2014  Sinergia grant from SNSF (with prof. Matthias Peter and Maurizio Molinari)-

    2015 – European Cooperation in Science and technology (COST) cooperation grant

    2016 – Marie Skłodowska-Curie Cofund grant

    2016 – ZonMW Medium Investment grant

    2017 – Marie Skłodowska-Curie Innovative Training Networks (ITN) grant

    2017 – ALW Open Program grant

    2018 – ZonMW TOP grant (with Prof. Haim Kampinga and Dr. Lukas Kapitein)


    Editorial boards

    Member of the Editorial Board of Autophagy since 2008.

    Member of the Editorial Board of Microbial Cell since 2013.

    Member of the Editorial Board of Oncotarget since 2015.

    Member of the Editorial Board of the Journal of Biological Chemistry since 2016.

    Member of the Editorial Board of the BBA Molecular Cell research since 2016.

    Member of the Editorial Board of the Journal of International Biochemistry and Cell Biology since 2018.


  • 2018

    Aksit, A. (2018). Peroxisomal membrane contact sites in the yeast Hansenula polymorpha [Groningen]: University of Groningen

    Rodrigues Abreu, S. (2018). New insights into autophagy regulation using yeast Saccharomyces cerevisiae. [Groningen]: University of Groningen.

    Rios Ocampo, W. (2018). Cellular stress response during hepatitis C virus infection: a balancing act between viral persistence and host cell survival. [Groningen]: Rijksuniversiteit Groningen. (Assessment cee,)


    van Duijl-Richter, M. (2016). Dengue and Chikungunya virus: Cell entry mechanisms and the impact of antibodies on infectivity [Groningen]: University of Groningen

    Yuan, W. (2016). Origin and growth of peroxisomes in yeast: The molecular mechanism of peroxisome formation in yeast [Groningen]: University of Groningen

  • Student projects:

    Although there is currently not a defined research project, the group often hosts students from the different Master Programmes at the University of Groningen. In addition, there are internship possibilities for technician trainees from the different Hogeschools in the Netherlands.

    You can apply via this application form.

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