The Sibon’s group focus is to understand Coenzyme A metabolism in health and disease. Coenzyme A is a central metabolic cofactor, known for over 60 years. In recent years, the awareness is increasing that Coenzyme A, in addition to its essential role in metabolism also plays a role in signal transduction, ageing, epigenetics and neurodegeneration.
Professor, Principal Investigator
Molecular and Cellular Biology
Hilda de Vries
Marianne de Villiers
The current view is that cells obtain their Coenzyme A via a de novo biosynthesis pathway starting with the uptake of vitamin B5. Recently the Sibon group showed that cells and organisms can also take up Coenzyme A from external sources. The mechanism behind this newly discovered manner of obtaining Coenzyme A is under investigation. The presence of this alternative route of intracellular Coenzyme A is of high importance for subjects suffering from inborn genetic errors of impaired Coenzyme A de novo biosynthesis, resulting in severe neurodegenerative diseases. Findings obtained in model organisms are being explored how to use external supplies of Coenzyme A to develop therapies for these diseases.
Ody C.M. Sibon received her PhD in 1994 in Molecular Cell Biology at the University of Utrecht, The Netherlands. She studied the topological organization of transcription and splicing at the ultrastructural level under the supervision of Prof. A.J. Verkleij. She then moved to the United States, were she studied the role of DNA checkpoint regulation during early embryonal development in Drosophila melanogaster at the University of Stoney brook, NY. Her postdoctoral advisor was prof. W.E. Theurkauf.
In 1998 she moved to the University of Groningen, the Netherlands were she started her own group. In 2002 she received a VIDI grant and in 2011 a VICI grant, both from the Dutch organization for Scientific research. Her research now is focussed on understanding the mechanisms of an altered Coenzyme A uptake route and the possibilities of this route in health and disease. She is named as inventor on several patents based on her discoveries related to Coenzyme A metabolism and she is developing these further towards therapies for Coenzyme A-related diseases. In 2009 she became a full professor. She is partner and/or coordinator of several European, American and Dutch grants.
See all dissertations supervised by Ody Sibon (promotor or assessor)
Pinto, F. (2018). Unraveling VPS13A pathways: from Drosophila to human. [Groningen]; University of Groningen
Monteiro Morgado, L. (2018). Computational Methods for High-Throughput Small RNA Analysis in Plants [Groningen]: University of Groningen
de Boer, P. (2018). Correlative microscopy reveals abnormalities in type 1 diabetes[Groningen]: Rijksuniversiteit Groningen
Li, Y. (2018). The identification of cell non-autonomous roles of astrocytes in neurodegeneration [Groningen]: University of Groningen
Yeshaw, W. M. (2018). VPS13A is a multitasking protein at the crossroads between organelle communication and protein homeostasis [Groningen]: University of Groningen
Vonk, J. (2017). Characterization of a Drosophila model for Chorea‐Acanthocytosis[Groningen]: University of Groningen
Dunham, J. T-N. (2017). Translational multiple sclerosis research in primates: Mind the gap [Groningen]: Rijksuniversiteit Groningen
Alvarenga Fernandes Sin, O. (2016). Aggregation-promoting factors in neurodegenerative diseases: Insights from a C. elegans model [Groningen]: University of Groningen
Baratashvili, M. B. (2016). Rescue strategies in Drosophila models of neurodegenerative diseases [Groningen]: Rijksuniversiteit Groningen
Smeets, C. J. L. M. (2016). The molecular neuropathology of spinocerebellar ataxia type 23 [Groningen]: Rijksuniversiteit Groningen
Laturney, M. E. (2016). The second sex: Functions and mechanisms of sperm manipulation in female Drosophila melanogaster [Groningen]: Rijksuniversiteit Groningen
Srinivasan, B. (2015). Rerouting ‘coenzyme A’ biosynthesis [Groningen]: University of Groningen
Siudeja, K. A. (2012). Coenzyme A as a central player in cellular and tissue homeostasis [S.n.]
Seinen, E. (2011). Small regulatory RNAs: identification, classification and utilizations.n.
Zijlstra, M. P. (2011). The role of heat shock proteins in polyQ disorders Groningen: s.n.
Vos, M. (2009). Small heat shock proteins: Implications for neurodegeneration & longevity s.n.
Interesting websites linked to the Sibon lab
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