Our ambition is to understand the molecular mechanisms that control the intracellular dynamics of proteins, lipids and membranes in the context of the functional organization of cells, and to understand how these mechanisms contribute to health or, when disrupted, to human disease.
In this context our focus is also on rare congenital disorders caused by disrupted intracellular protein dynamics and cellular organization, which includes elucidating their pathogenesis, development of patient-specific iPSC-based cell models and lead identification for novel therapeutic strategies.
Professor, Principal Investigator
Cell Biology, Intracellular protein trafficking, cellular organization
Lucja Jarosz, 2012-2014
Sukhdeep Galsinh, 2013
Nai-Hua Hsiao, 2009-2011
Matsushita Masafumi Matsushita, 2010
Chris Mee, 2010
Ryuichi Ohgaki, 2009
Kati Juuti-Uusitalo, 2009-2010
Chris Mee, 2008
Kousei Ito, 2008
Tounsia Ait-Slimane, 2004
Tetsuo Nakayima, 2004
Leon Klunder, 2012-2016
Herschel Dhekne, 2010-2014
Christiaan Slim, 2010-2014
Magdalena Golachowska, 2007-2011
Kacper Wojtal, 2003-2007
Delphine Théard, 2002-2006
Joke van der Wouden, 2000-2004
Sven van Ijzendoorn received his Master degree at the University of Maastricht in 1995 and his PhD degree (cum laude) at the University of Groningen (laboratory of Dick Hoekstra) in 1999. With a long-term fellowship of the Human Frontier Science Program (HFSP) he performed his postdoctoral studies at the University of California San Francisco (UCSF) in the laboratory of Keith Mostov.
He then returned to the Netherlands to start his research group in the department of Cell Biology at the University Medical Center Groningen, where he is currently appointed as full professor. His research focusses on the molecular mechanisms that control the intracellular dynamics of proteins, lipids and membranes in the context of the functional organization of cells, and to understand how these mechanisms contribute to health or, when disrupted, to human diseases. In this context, his research also focusses on elucidating the pathogenesis of rare congenital disorders, develop patient-specific iPSC-based cell models and identify leads for novel therapeutic strategies.
Sven van Ijzendoorn is member of the board of the Netherlands Association for the Study of the Liver (NASL), member of the advisory board of the Dutch Society for Cell Biology, member of the editorial board of ‘Tissue Barriers’, curator of the international registry of patients with microvillus inclusion disease, and program leader of the UMCG Center for Liver, Digestive & Metabolic Diseases.
|Effects of lifestyle and environmental factors on intestinal epithelial cell morphogenesis
2016, Klunder,L.J. (Leon)
GUIDE / CLDM: Center for Liver, Digestive and Metabolic Diseases
Intestinal epithelium, the innermost cell layer of the intestine is capable of taking up nutrients and fluid, and forming an otherwise impermeable layer. In order to do this, intestinal epithelial cells must have the capacity to organize themselves internally as well as in respect to neighbor cells; a tightly regulated process. In this process an epithelial cell creates memb…
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