PhD student for ‘Nuclear Protein Quality Control’

PhD student for ‘Nuclear Protein Quality Control’

Department Biomedical Sciences of Cells & Systems (BSCS)
Work location Groningen
Apply no later than 15 July 2019

Working environment

The Department of Biomedical Sciences of Cells and Systems (BSCS) conducts human biology research and teaching at sector O&O of the University Medical Center Groningen (UMCG). The department is composed of four sections and the studies within the department focused on understanding basic functions and processes of the cell & systems and how they lead to disease if disturbed. The specific research program of the section Molecular Cell biology constitutes several aspects of cell biology, including protein homeostasis, protein complex remodeling, and organelle maintenance and sorting. Model systems include yeast, mammalian cell and (patient-derived) iPS cell models, somatic stem cells, organoids and organotypic slice models, and Drosophila and mouse models. Diseases studied encompass neurodegenerative diseases, (cardio)myopathies, gastroenterological diseases, dermatological diseases and oncology. The department is embedded in Graduate School Medical Sciences (GSMS) and the Research School BCN.

Job description

A four-year PhD/AIO position is available in the lab of dr. Mark Hipp in the section Molecular Cell biology, department of BSCS.
Protein aggregation is associated with neurodegeneration and many other age-related pathologies. We have recently demonstrated that the nuclear environment interferes with protein aggregation and disfavors aberrant interactions of aggregation-prone proteins with endogenous factors (Woerner et al., Science 2016). The aim of this project is to characterize the quality control components in the nucleus that prevent aggregation-mediated toxicity, and develop methods to exploit their protective functions. To do this we will study the fate of disease related mutant proteins and artificial model substrates in the nuclei of yeast and cultured mammalian cells, and develop markers/sensors to characterize the cellular response to the presence of these proteins.

What do we need

  • Required education/skills: MSc in bio-medicine related subject
  • Interest in molecular cell biology
  • Previous experience in cell biology and light microscopy is a pro
  • Excellent writing and speaking/presentation skills in English
  • Active engagement in scientific discussion
  • Ability to think and work independently, owning responsibility, and have a positive attitude towards challenges
  • Should be proactive, enthusiastic, and a team player

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.


What do we offer

The University of Groningen offers a salary of € 2.357,- gross per month in the first year up to a maximum of € 3.020,- gross per month in the last year (scale PRO)
In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus.
The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

It concerns a full time appointment (36 h/week) for a period of four years to be concluded with a PhD examination. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to expect a successful completion of the PhD thesis within the coming three years.

More information: 
For more information about this vacancy you may contact:
dr. Mark Hipp, or prof. Harrie Kampinga, head of the department, (please do not use e-mail addresses for applications).

Applying for a job

Please use the the digital application form at the bottom of this page – only these will be processed.
You can apply until 15 July 2019.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.

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